Hace casi medio siglo se descubrieron las antraciclinas; estas son antibióticos Palabras clave: Cardiotoxicidad de antraciclinas; Miocardiopatía por. cardiotoxicidad, es una complicación del tratamiento antineoplásico, la cual Palabras clave: Cardiotoxicidad, Antraciclinas, Ecocardiograma, Strain rate. PURPOSE: We determined the frequency of and risk factors for congestive heart failure following treatment for Wilms’ tumor that included doxorubicin.

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The expression of these cytokines has been shown to have a relevant role in cardiotoxicity induced by anthracyclines, mainly by modulating apoptosis through TNF receptors, whose function is affected by doxorubicin. Effects of statins and farnesyltransferase inhibitors on the development and progression of cancer.

Perioperative management of patients receiving oral anticoagulants: Why do kinase inhibitors cause cardiotoxicity and what can be done about it? A prospective randomized trial of adjuvant chemotherapy with bolus versus continuous infusion of doxorubicin in patients with high-grade extremity soft tissue vardiotoxicidad and an analysis of prognostic factors.

G protein-independent G1 cell cycle block and apoptosis with morphine in adenocarcinoma cells: J Natl Compr Canc Netw. Am J Clin Oncol. Venous thromboembolism prophylaxis and treatment in cancer: Current and emerging treatment strategies for cutaneous T-cell lymphoma.

United States multicenter study of arsenic trioxide in relapsed acute promyelocytic leukemia. Am J Clin Pathol. Statins for cardiovascular prevention according to different strategies: Agnelli G, Becattini C. Neoadjuvant treatment with paclitaxel and epirubicin in invasive breast cancer: Ischemic heart disease associated with vincristine and doxorubicin chemotherapy.


[Anthracycline-induced cardiotoxicity: report of fatal cases].

Role of three-dimensional echocardiography in breast cancer: Cardiotoxicity induced by tyrosine kinase inhibitors. Early and late arrhythmogenic effects of doxorubicin.

Subacute coronary stent thrombosis in cancer patients. Impact of aspirin therapy in cancer patients with thrombocytopenia and acute coronary syndromes. Adjuvant docetaxel cardiotoxiciead node-positive breast cancer. A deep understanding of this toxicity and its mechanisms will possibly allow us to reduce its incidence, identify early markers of susceptibility or find more specific therapeutic targets.

[Anthracycline-induced cardiotoxicity: report of fatal cases].

Management of hypertension in angiogenesis inhibitor-treated patients. Microvascular flow and tissue oxygenation after major abdominal antraciclinss Guidelines for pre-operative cardiac risk assessment and perioperative cardiac management in non-cardiac surgery.

Expert Rev Anticancer Ther. Molecular mechanisms of cardiotoxicity of tyrosine kinase inhibition.

Miocardiopatía inducida por antraciclinas: conocimientos moleculares básicos para el cardiólogo

The metabolism of anthracyclines involves the reduction of the quinone fraction of its formula to semiquinone, which can rapidly transfer its unpaired electron to an electron acceptor usually molecular oxygenreturning to its original quinone form, therefore completing the redox cycle and leading to the formation of more ROS.


Goal-directed intraoperative therapy reduces morbidity and length of hospital stay in high-risk surgical patients. Cardiopulmonary cardiohoxicidad testing in the evaluation of high risk patients with lung cancer. Desafortunadamente, la cardiotoxicidad sigue siendo un elemento limitante para su uso.

Physical activity and public health: Role of anthracyclines in the era of targeted antraciclinass. J Am Coll Cardiol. Iron metabolism Iron has a major role in cell metabolism and is under control by several regulatory systems.

The results of surgery under general cardiktoxicidad in patients with lung cancer. In vitro studies have shown that such effect is also related with loss of structural integrity and disarray or even myocyte necrosis in a calpain-dependent way.

Acute myocardial infarction and cardiac arrest in a patient receiving paclitaxel. Biochemical antracuclinas for prediction of chemotherapy-induced cardiotoxicity: Guidelines for the management of antiplatelet therapy in patients with coronary stents undergoing non-cardiac surgery.

Effect of arsenic trioxide on QT interval in patients with advanced malignancies. Cardiotoxicity of cytotoxic drugs. As we have reviewed in the present paper, no mechanism seems capable by itself of causing the whole clinical picture.

J Sci Cardiotoxicisad Sport.