PI = Prescribing Information / SUV = Single Use Vial / SDV = Single Dose Vial / MDV = Multi Dose Vial / N/A: Not Applicable / LF: Latex Free / PF: Preservative. Medscape – Indication-specific dosing for colistimethate sodium, Coly Mycin M ( colistin), frequency-based adverse effects, comprehensive interactions. Drug Information on Coly Mycin M (colistimethate) includes drug pictures, side effects, drug interactions, directions for use, symptoms of overdose, and what to.

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Since colistimethate sodium is eliminated by the kidney, coadministration with other potentially nephrotoxic drugs, including bacitracin, may increase serum concentrations of either drug.

Be careful if you drive or do anything that requires you to be alert. However, a study in Yersinia spp. PAE occurs when suppression of bacterial growth continues after the antibiotic concentration falls below mycon bacterial MIC.

Alternatively, colistimethate sodium mhcin to 2. Theoretically, the chronic coadministration of these drugs may increase the risk of developing nephrotoxicity, even in patients who have normal renal function. It is not known whether colistimethate sodium is excreted in human milk.

Coly-Mycin M | Par Sterile Products

Another study of 60 patients with multi-drug resistant gram-negative infections showed a favorable response in Additionally, neuromuscular blockade has been associated with colistimethate sodium, and is more likely to occur in patients with renal dysfunction. Swirl gently to avoid frothing. Major Both colistimethate sodium and carboplatin can cause nephrotoxicity. Moderate Tacrine can potentiate the neuromuscular blocking effect of colistimethate sodium by impairing transmission of impulses at the motor nerve terminals.

Medically reviewed by Drugs. Specific guidelines for dosage adjustments in hepatic impairment are not available; it appears that no dosage adjustments are needed. Colistimethate sodium is hydrolyzed in vitro to colistin base and is extensively cleared renally via filtration and net renal tubular secretion.


This results from decreased colistimethate sodium elimination, which would result in a higher proportion of colistimethate jycin being available for hydrolysis to colistin base.

Tell your doctor if you are breast-feeding. Also of concern is the emergence of a heteroresistant population of Acinetobacter baumannii that shows bacterial regrowth within 24 hours of exposure to colistimethate sodium therapy. The dose should be inhaled over 10 to 15 minutes; studies have used the following nebulizers: In some cases, this medicine is given over a period of up to 23 hours.

Consider pseudomembranous colitis as a potential diagnosis in patients presenting with diarrhea after antibacterial administration. Premixing colistimethate into an aqueous solution and storing it for longer than 24 hours results in increased concentrations of colistin base in solution, increasing the potential for lung toxicity.

Amphotericin B liposomal LAmB: Therefore, use colistimethate kycin during pregnancy only if the potential benefit justifies the potential risk to the fetus.

A study of 60 patients with nosocomial infections caused by Mucin aeruginosa or Acinetobacter baumannii receiving colistimethate sodium at doses equivalent to 2. Emtricitabine; Tenofovir disoproxil fumarate: Colistimethate sodium, which is the parenteral formulation, is an inactive pro-drug of the bioactive form colistin base. We comply with the HONcode standard for trustworthy health information – verify here. You may need to stop using the medicine for a short time.

Subscribe to free Drugs. A study using HPLC assays in 12 cystic fibrosis patients showed that for colistimethate sodium, the total body clearance mycim 2. Nebulized use of colistimethate sodium has been possibly associated with the death of a cystic fibrosis CF patient.


For continuous IV infusion, administer one-half of the total daily dose IV bolus over 3 to 5 minutes, then 1 to 2 hours later give the remainder of the daily dose by continuous IV infusion over 22 to 23 hours.

Moderate Depolarizing neuromuscular blockers and non-depolarizing neuromuscular blockers can potentiate the neuromuscular blocking effect of colistimethate sodium. Closely monitor renal function. Major The manufacturer of entecavir recommends monitoring for adverse effects when administered with potentially nephrotoxic agents, such as colistimethate sodium.

Two inhalations, each consisting of Do not use anti-diarrhea medicine unless your doctor tells you to. Follow all directions on your medicine label and package.

Coly Mycin M Uses, Side Effects & Warnings –

Colistimethate sodium has also been reported to interfere with nerve impulse transmission at the neuromuscular junction. Moderate Quinidine can potentiate the neuromuscular blocking effect of colistimethate sodium by impairing transmission of impulses at the motor nerve terminals. Coadminister IG copy at the minimum concentration available and the minimum rate of infusion practicable. By clicking Subscribe, I agree to the Drugs. It was previously thought that antibiotics may decrease the effectiveness of OCs containing estrogens due to stimulation of metabolism or a reduction in mycim circulation via changes in GI flora.

Use within 7 days.

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Call your doctor for medical advice about side effects. Dosing recommendations based on current peritoneal dialysis practices are not available; monitor patients closely. If you have diarrhea that is watery or bloody, call your doctor.